A Watermelon-Like Micro/Nano Hierarchical Delivery Platform for Ulcerative Colitis by Regulating Redox Homeostasis and Remodeling Gut Microbiota - PubMed
6 hours ago
- #Drug Delivery
- #Microbiome
- #Inflammatory Bowel Disease
- A 'watermelon-like' micro/nano hierarchical hydrogel microsphere system (QC@HACM) is developed for ulcerative colitis (UC) therapy.
- QC@HACM encapsulates chondroitin sulfate-based nanoparticles (Qu@CSCP) with quercetin in a hyaluronic acid/calcium alginate hydrogel shell.
- The platform targets inflamed colon tissue, protects cargo from the GI tract, and adheres to the colon for localized delivery.
- It regulates redox homeostasis by activating the Nrf2/HO-1 antioxidant pathway and suppressing epithelial apoptosis.
- QC@HACM remodels gut microbiota by enriching probiotics and promotes mucosal healing through tight junction protein expression.
- In a murine UC model, it reduces pro-inflammatory cytokines and restores gut microbiota homeostasis, showing therapeutic efficacy.