HNF4α-HKDC1 axis orchestrates a metabolic rewiring to promote migration and metastasis in advanced gastric cancer - PubMed
4 hours ago
- #HNF4α-HKDC1 axis
- #metastasis
- #gastric cancer
- P2-HNF4α is highly expressed in distant metastasis of gastric cancer (GC) and promotes GC cell migration and metastasis.
- The HNF4α-HKDC1 axis orchestrates metabolic rewiring to facilitate GC migration and metastasis.
- Mycophenolic acid suppresses HKDC1 expression and inhibits GC migration and metastasis by antagonizing HNF4α.
- The study highlights the HNF4α-HKDC1 axis as a potential therapeutic target for metastatic GC.