Interleukin-6-Associated Pyroptosis, Apoptosis, and Necroptosis via JAKs/STAT3-RIPK1 Axis: A Potential Mechanism for CD4+ T-Cell Depletion in Bacterial Sepsis - PubMed
3 days ago
- #Sepsis
- #PANoptosis
- #CD4+ T-cell depletion
- Study investigates CD4+ T-cell depletion in bacterial sepsis via IL-6/JAKs/STAT3-RIPK1 axis.
- Findings show IL-6 induces pyroptosis, apoptosis, and necroptosis (PANoptosis) in CD4+ T cells.
- Inhibition of JAKs/STAT3 or RIPK1 reduces PANoptosis and partially restores CD4+ T-cell viability.
- Research suggests PANoptosis as a key mechanism in sepsis-related immunosuppression.