Consciousness Disturbances Reported With Clindamycin Versus Cefazolin in Surgical Patients: A Global Pharmacovigilance Analysis Using VigiBase - PubMed
6 hours ago
- #Surgical Prophylaxis
- #Pharmacovigilance
- #Clindamycin
- Clindamycin is commonly used as a β-lactam substitute for surgical prophylaxis.
- A pharmacovigilance analysis using WHO VigiBase found a disproportionality signal for consciousness disturbances with clindamycin compared to cefazolin.
- The adjusted reporting odds ratio (aROR) for clindamycin vs. cefazolin was 2.23, indicating higher reporting of consciousness disturbances with clindamycin.
- Sensitivity analyses, excluding sepsis-related terms and syncope, yielded similar results, reinforcing the signal.
- Clustering analysis identified co-reporting patterns involving lidocaine, sedatives/anesthetics, and opioids across different age groups and acuity markers.
- The study is hypothesis-generating and does not estimate incidence or comparative risk due to limitations of spontaneous reporting data.
- Further evaluation in data sources with exposure denominators and prospective clinical characterization is recommended.