Keratin 16 inhibits type I interferon responses in differentiating keratinocytes of stressed and diseased skin - PubMed
3 hours ago
- #Keratin 16
- #Type I Interferon Signaling
- #Inflammatory Skin Diseases
- Keratin 16 (K16) is a stress-induced protein that negatively regulates type I interferon (IFN) signaling and innate immune responses in the skin.
- Loss of K16 leads to enhanced IFN signaling, as seen in palmoplantar keratoderma lesions of individuals with pachyonychia congenita (PC) and exacerbated inflammation in mouse models.
- K16 interacts with effectors of the RIG-I-like receptor pathway, such as 14-3-3β, inhibiting the 14-3-3β:RIG-I interaction and thereby suppressing IFN activation upstream.
- Topical application of the Janus kinase inhibitor ruxolitinib reduces lesion severity in Krt16-null mice, suggesting potential therapeutic strategies for PC and related inflammatory skin disorders.