Landouzy sepsis in a young adult with multiorgan failure: successful ECMO-assisted management using an individualized antituberculous regimen - PubMed
3 hours ago
- #ECMO
- #Landouzy sepsis
- #Individualized antituberculous regimen
- A 23-year-old man with miliary tuberculosis developed Landouzy sepsis, ARDS, and multiorgan failure.
- He required prolonged VV and VVV ECMO support for six weeks due to refractory hypoxemia.
- An individualized antituberculous regimen was used due to liver injury, initially avoiding first-line drugs.
- The tailored regimen included ethambutol, isoniazid, levofloxacin, bedaquiline, and amikacin.
- Corticosteroids were added for suspected organizing pneumonia, leading to clinical improvement.
- Complications included thrombocytopenia, pneumothorax, arrhythmia, hyperbilirubinemia, and amikacin-induced hearing loss.
- Microbiological clearance was achieved, organ function recovered, and first-line therapy was later reintroduced.
- The patient was discharged without oxygen and entered a rehabilitation program.