Preformed donor-specific antibodies are associated with acute rejection and biliary complications after liver transplantation: A Swiss Transplant Cohort Study analysis - PubMed
7 hours ago
- #Donor-Specific Antibodies
- #Liver Transplantation
- #Biliary Complications
- Preformed donor-specific antibodies (DSA) are present in 28.7% of liver transplant recipients, with higher rates in those with prior transplants or autoimmune liver disease.
- DSA-positive patients with a cumulative mean fluorescence intensity (cMFI) ≥5000 face increased risks of allograft failure and biopsy-proven acute rejection.
- Preformed DSA are independently linked to biliary complications after transplantation, but not to vascular or infectious issues, highlighting the need for pre-transplant immunological risk assessment and tailored immunosuppression.