Risk in Women Emerges at Lower Coronary Plaque Burden Than in Men: PROMISE Trial - PubMed
3 hours ago
- #sex differences
- #coronary plaque
- #cardiovascular risk
- The study found that women experience cardiovascular risk at lower levels of coronary plaque burden compared to men.
- Data from the PROMISE trial showed that major adverse cardiovascular events (MACE) became elevated at a total plaque burden (PB) of 20% in women versus 28% in men.
- Noncalcified plaque burden also showed a similar pattern, with risk crossing hazard ratio 1.0 at 7% in women versus 9% in men.
- Women had less frequent plaque presence (55% vs. 75%) and lower total plaque volume but similar total PB and incident MACE rates compared to men.
- The findings suggest the need for sex-specific interpretation of coronary computed tomography angiography (CCTA)-derived plaque metrics for timely intervention in women.