Advanced, pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions: a systematic evidence map with selective meta-analyses - PubMed
3 hours ago
- #photobiomodulation
- #meta-analysis
- #orofacial pain
- Systematic evidence map and meta-analyses on interventions for chronic or recurrent orofacial pain (OP).
- Focus on temporomandibular disorders (TMD), burning mouth syndrome (BMS), trigeminal neuralgia (TN), and other OP phenotypes.
- 130 studies included (n=6879 participants), with both randomized and non-randomized intervention studies.
- Photobiomodulation or low-level laser therapy (PBM/LLLT) showed short-term pain reduction in BMS (moderate certainty).
- Most pharmacologic and supplement interventions for BMS had uncertain or inconsistent effects.
- Evidence for TMD varied by modality and comparator, generally low or very low certainty.
- Sparse evidence for TN and digital therapeutics, with inconsistent adverse-event reporting.
- Future trials should standardize outcomes, extend follow-up, and report harms transparently.