Calcific Aortopathy in Response to Aging and Injury - PubMed

4 days ago

Calcific aortopathy is a common condition in aging populations, particularly in westernized societies.
Calcification often starts in the abdominal aorta before affecting the thoracic aorta and aortic valves.
Conditions like metabolic syndrome, chronic kidney disease, and irradiation can accelerate calcification.
Calcification is linked to increased cardiovascular mortality and neurocognitive decline.
Recent research highlights the role of innate immunity, senescence, and osteogenic mechanisms in calcific aortopathy.
There is potential for new medical treatments to prevent or treat calcific aortopathy in the coming decade.

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