Persistent homology analysis of longitudinal CT fibrotic features in COPD - PubMed
5 hours ago
- #COPD
- #Persistent Homology
- #CT Fibrosis
- Persistent homology (PH) analysis is used to quantify fibrotic lesions in COPD patients via CT scans.
- The study involved subjects from the Lung Cancer Screening cohort and two prospective COPD cohorts.
- Higher PH-fibrosis% was associated with interstitial lung abnormalities (ILAs) and future exacerbation risks.
- PH-fibrosis% showed significant associations with increased mortality in COPD patients.
- Longitudinal increases in PH-fibrosis% correlated with higher exacerbation frequency and mortality.
- PH-based fibrosis quantification could serve as a prognostic imaging marker in COPD.