Multi-modal dissection of cell-type specific TDP-43 pathology in the motor cortex - PubMed
3 days ago
- #TDP-43
- #ALS
- #neurodegeneration
- Study focuses on TDP-43 pathology in ALS/ALS-FTD, identifying affected cell types in the motor cortex.
- Excitatory cortical neurons, including specific subtypes like L2-L3-LINC00507-FREM3 and L5-FEZF2-NTNG1, are most affected by TDP-43 pathology.
- Transcriptional changes due to TDP-43 pathology are cell-type specific, emphasizing the need for targeted therapeutic approaches.
- Multi-omic approaches (ATAC-seq, RNA-seq, spatial transcriptomics) were used on post-mortem samples (30 ALS, 20 ALS-FTD, 32 controls).
- Findings highlight the importance of addressing TDP-43 pathology in a cell-type specific manner for ALS/ALS-FTD treatment.