Cancer Risk in Solid Organ Transplant Recipients With a Pretransplant Cancer History - PubMed
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- #medical research
- #cancer risk
- #organ transplant
- Cancer survivors and solid organ transplant (SOT) recipients both have elevated risks of developing subsequent cancers.
- The study evaluates the association between pretransplant cancers and posttransplant cancer risk among SOT recipients using data from the US Scientific Registry of Transplant Recipients and 34 cancer registries.
- Seven types of pretransplant cancer were significantly associated with the same type of cancer posttransplant: breast, melanoma, lung, kidney, urinary bladder, liver, and colorectal cancers.
- Other significant associations include liver cancer followed by lung or prostate cancer, urinary bladder followed by lung cancer, kidney followed by thyroid cancer, and intrahepatic bile duct followed by pancreatic cancer.
- The incidence rate ratios (IRRs) for these associations were generally lower than the standardized incidence ratios (SIRs) for cancer survivors in the general population for liver-liver, kidney-kidney, and lung-lung cancer combinations.
- The findings suggest that shared genetic or environmental risk factors, as well as underlying end-stage organ disease, may contribute to the elevated cancer risk in SOT recipients with a pretransplant cancer history.
- Targeted cancer prevention and screening are recommended for SOT recipients who have had a cancer diagnosis before transplant.