Exosomes Regulate the NLRP3/Caspase-1/IL-1β Signaling Pathway in Parkinson's Disease: Mechanisms of Neuroinflammation Modulation and α-Synuclein Propagation - PubMed
3 days ago
- #exosomes
- #Parkinson's disease
- #neuroinflammation
- Exosomes play a dual role in regulating the NLRP3/Caspase-1/IL-1β signaling pathway in Parkinson's disease (PD).
- Pro-inflammatory exosomes from microglia and neurons contain NLRP3, ASC, α-syn oligomers, and pro-IL-1β, exacerbating neuroinflammation and dopaminergic neuronal pyroptosis.
- These exosomes trigger mitochondrial ROS overproduction and intracellular K+ efflux, activating the NLRP3 inflammasome and promoting α-synuclein propagation.
- Microglial exosomes from PD models show 2-3-fold higher NLRP3 expression compared to controls.
- Targeting the exosome-NLRP3/Caspase-1/IL-1β axis could offer therapeutic potential for PD.