Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment - PubMed
4 hours ago
- #Liver Metastasis
- #Tumor Microenvironment
- #Ammonia Detoxification
- Ammonia accumulation from disrupted removal processes creates a liver environment conducive to metastasis.
- Cancer cell hyperactivation of de novo pyrimidine biosynthesis impairs the urea cycle, leading to ammonia buildup.
- Ammonia remodels the liver by inducing metastasis-associated fibroblasts, suppressing protective macrophages, and expanding pro-metastatic neutrophils.
- The ammonia detoxifier LOLA reshapes the microenvironment, reduces metastatic burden, and shows therapeutic promise.