Therapeutic effects of hypoxia-preconditioned cartilage progenitor cell-exosomes on osteoarthritis through autophagy activation and macrophage polarization modulation - PubMed
12 hours ago
- #exosomes
- #autophagy
- #osteoarthritis
- Hypoxia-preconditioned cartilage progenitor cell-exosomes (H-Exos) show superior regenerative capabilities for osteoarthritis (OA) treatment.
- H-Exos promote proliferation and migration while suppressing catabolism in IL-1β-treated ATDC5 cells.
- Hypoxic preconditioning enriches miR-222-3p in H-Exos, targeting Rab1A to inhibit mTORC1 signaling and restore autophagy.
- H-Exos drive macrophage polarization toward an anti-inflammatory phenotype by inhibiting the NF-κB signaling pathway.
- Intra-articular delivery of GelMA/H-Exos composite hydrogel in a rat OA model significantly attenuates cartilage destruction and modulates synovial macrophage polarization.
- The study presents a dual protective mechanism involving the miR-222-3p-Rab1A-mTORC1-autophagy axis and macrophage reprogramming for OA therapy.