Identifying a cancer therapeutic target: Cell-SELEX identifies a membrane protein for aptamer-mediated growth suppression - PubMed
4 hours ago
- #aptamer
- #SLC25A24
- #cancer therapy
- Cell-SELEX identified a DNA aptamer, CW06, targeting breast cancer cells.
- Apt-MGPH revealed mitochondrial solute carrier SLC25A24 as the aptamer's target.
- CW06 treatment upregulated SLC25A24, disrupting methionine metabolism and inducing cell cycle arrest.
- In mouse models, CW06 inhibited tumor growth without affecting healthy tissues.
- Targeted degradation of SLC25A24 reversed the effects, confirming its role in metabolism-senescence.
- Apt-MGPH is a robust tool for membrane target identification in cancer therapy.