Src promotes tumor cell invasion by hijacking the translation machineries - PubMed
4 hours ago
- #translation initiation
- #invadosomes
- #cancer
- Src oncogene promotes tumor cell invasion by hijacking translation machineries.
- Src regulates mRNA translation and controls eIF3 subunits (eIF3h, eIF3e, eIF3d), crucial for invadosome formation and ECM degradation.
- Src activates both canonical (PI3K/AKT/mTOR) and non-canonical (eIF3d) translation mechanisms for invadosome function.
- Overexpression of Src and eIF3h/e/d correlates with poor prognosis in hepatocellular carcinoma (HCC).
- Study identifies Src as a key regulator of translation initiation, invadosome formation, and tumor invasiveness.