Developing Inner Ear Organoids in Ultrasound-Activated Piezoelectric Hydrogel for Assessing Ototoxicity - PubMed
8 hours ago
- #inner ear organoids
- #piezoelectric hydrogel
- #ototoxicity screening
- Researchers developed inner ear organoids (IEOs) from human induced pluripotent stem cells using a barium titanate-doped GelMA hydrogel that generates piezoelectric potential under ultrasound, aiding auditory neuron differentiation and maturation.
- The bioengineered IEOs formed otic-vesicle-like structures and functional hair cells and sensory neurons, offering a platform for drug testing.
- The study demonstrated resveratrol's effectiveness in mitigating cisplatin-induced ototoxicity and neuropathy in IEOs, suggesting potential for innovative drug screening systems.