The medial orbitofrontal cortex mediates neuropathic pain and anxiodepressive-like behaviors via two distinct pathways - PubMed
5 hours ago
- #mOFC
- #Neuropathic pain
- #Anxiety and depression
- The medial orbitofrontal cortex (mOFC) plays a key role in neuropathic pain and anxiodepressive-like behaviors.
- Neuropathic pain was induced via chronic constriction injury (CCI) of the sciatic nerve in mice.
- mOFC glutamatergic neurons are activated in neuropathic pain and contribute to both pain hypersensitivity and anxiodepressive-like behaviors.
- Two distinct pathways were identified: mOFCCaMKIIα-MD (mediates pain hypersensitivity) and mOFCCaMKIIα-BLA (mediates anxiodepressive-like behaviors).
- Inhibition of mOFC glutamatergic neurons alleviates both pain and affective disturbances in neuropathic pain models.