Respiratory viral infections prime accelerated lung cancer growth - PubMed
a day ago
- #viral pneumonia
- #COVID-19
- #lung cancer
- Patients previously hospitalized with severe COVID-19 have an increased risk of subsequent lung cancer.
- Severe respiratory viral infections accelerated lung cancer growth in murine models, while vaccination mitigated this effect.
- Viral pneumonia reprograms the lung into a pro-tumor microenvironment with sustained tumor-associated neutrophils and heightened immunosuppression.
- Persistent chromatin remodeling at key cytokine loci links inflammatory memory to tumor-promoting signals.
- Combined blockade of neutrophil recruitment and PD-L1 restored CD8+ T cell function and suppressed tumor growth.
- Findings establish a causal link between viral pneumonia and lung tumorigenesis, highlighting the need for enhanced surveillance and targeted interventions.