Tet2-driven clonal hematopoiesis drives aortic aneurysm via macrophage-to-osteoclast-like differentiation - PubMed
3 hours ago
- #aortic-aneurysm
- #clonal-hematopoiesis
- #macrophage-differentiation
- Aortic aneurysms are age-related dilations with high rupture mortality.
- Clonal hematopoiesis, linked to age, reshapes immune function and contributes to diseases.
- Tet2-deficient bone marrow transplants in mice led to greater aortic dilation.
- Tet2-deficient macrophages adopted an osteoclast-like state, producing more MMP9.
- Inhibition of osteoclast-like differentiation suppressed aneurysmal growth.
- Tet2-driven clonal hematopoiesis accelerates aneurysm via MMP9-producing macrophages.