Dual-functional tea polyphenol-serotonin nanoparticles for integrated inflammation suppression and mucosal repair in inflammatory bowel disease - PubMed
3 hours ago
- #Inflammatory Bowel Disease
- #Drug Delivery
- #Nanomedicine
- Developed tea polyphenol-serotonin nanoparticles (TPSNs) for IBD treatment.
- TPSNs combine anti-inflammatory, antioxidant, and mucosal repair functions.
- Effective in acute and chronic colitis models in zebrafish and mice.
- Mechanisms include RONS scavenging, macrophage repolarization, and NF-κB inhibition.
- Enhanced epithelial cell proliferation via MAPK and PI3K-AKT pathways.
- Incorporated into thermosensitive gel for localized rectal drug delivery.
- Showed significant symptom and histopathological improvement with no major toxicity.