Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism - PubMed
8 hours ago
- #osteoclastogenesis
- #bone homeostasis
- #Collectin-11
- Collectin-11 (CL-11) regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism.
- Combined deficiencies of CL-11 with complement components (MASP-2, factor B, or C3) lead to vertebral bone loss and spinal curvature in mice by 12 weeks.
- CL-11 and complement are crucial for osteoclast (OCL) differentiation, as shown in both mouse and human models.
- CL-11 and the membrane attack complex (C5b-9) colocalize in OCLs and their precursors throughout life.
- CL-11 is identified as a key regulator of bone homeostasis and a potential therapeutic target for bone-related disorders.