Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux - PubMed
5 days ago
- #cancer
- #autophagy
- #extracellular matrix
- Autophagy is a self-eating process involved in diseases like pancreatic ductal adenocarcinoma (PDA).
- PDA cells regulate autophagy via the integrinα3-Hippo-YAP1 axis by sensing the extracellular matrix (ECM).
- Proximity to ECM influences autophagy levels, leading to heterogeneous responses: low autophagy cells are proliferative, while high autophagy cells tolerate chemotherapy better.
- Targeting ECM-mediated autophagy regulation reduces heterogeneity, alters tumor growth, and improves therapy responses.
- The study reveals a non-metabolic regulation of autophagy through ECM sensing, offering new therapeutic avenues.