MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer - PubMed
8 hours ago
- #stress response
- #MYC network
- #pancreatic cancer
- MondoA is essential for viability in pancreatic ductal adenocarcinoma (PDAC) cell lines with amplified MYC.
- Loss of MondoA alters expression of MYC target genes and shifts genomic occupancy of MYC network members.
- MondoA inhibition disrupts coordination between the MYC network and the Integrated Stress Response (ISR), leading to apoptosis.
- Restoring ATF4 protein expression rescues viability loss caused by MondoA inhibition.
- Small-molecule inhibition of MondoA is lethal in certain PDAC cell lines and patient-derived organoids.