Subversion of kynurenine-induced AHR activation in CD8 T cells by kynureninase-expressing antigen-presenting cells - PubMed
4 hours ago
- #CD8 T cells
- #antitumor immunity
- #kynurenine pathway
- Kynurenine, a tryptophan metabolite, suppresses CD8+ T cell antitumor activity via AHR activation.
- KYNU is mainly expressed in antigen-presenting cells (APCs) and degrades kynurenine without aiding NAD+ synthesis.
- CD8+ T cells uptake kynurenine but lack KYNU, leading to immunosuppression.
- KYNU-expressing APCs can deplete extracellular kynurenine, preventing AHR activation and restoring IFN-γ production in CD8+ T cells.
- This study highlights the role of KYNU-expressing APCs in countering kynurenine-induced immune suppression in tumors.