Combination of Vaccine With IL-12-Armed Oncolytic Virus SKV-012 Synergistically Potentiates Immune Responses in HPV-Associated Malignancies - PubMed
3 hours ago
- #HPV vaccine
- #immunotherapy
- #oncolytic virus
- An adenoviral therapeutic vaccine encoding HPV E7 epitope (Ad-E7P) significantly inhibited tumor growth in HPV-induced murine models.
- Combination of the vaccine with IL-12-armed oncolytic herpesvirus (SKV-012) enhanced antitumor responses, leading to tumor clearance.
- The combination therapy promoted antigen-specific T-cell expansion, remodeled the tumor microenvironment, and generated immune memory.