Synergistic disruption of the blood-brain barrier in tree shrews by Methamphetamine and HIV-1 Tat via TRPM2-Mediated astrocyte inflammation - PubMed
4 hours ago
- #Blood-brain barrier
- #TRPM2
- #Neuroinflammation
- Methamphetamine (METH) and HIV-1 Tat protein (Tat) synergistically disrupt the blood-brain barrier (BBB) in tree shrews.
- The disruption is mediated via TRPM2 channels in astrocytes, leading to neuroinflammation and BBB damage.
- Both in vitro and in vivo models showed that METH and Tat decrease tight junction proteins and increase BBB permeability.
- Pharmacological inhibition or astrocyte-specific knockdown of TRPM2 mitigated BBB damage and neuroinflammation.
- TRPM2 inhibition also alleviated METH + Tat-induced behavioral impairments in tree shrews.
- The study identifies TRPM2 as a potential therapeutic target for neurotoxicity caused by METH and HIV-1 Tat.