Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging - PubMed

3 hours ago

Extracellular vesicles (EVs) from senescent hepatocytes promote metastasis across various tumor types in aging mice.
Aged liver tissue shows increased expression of P2RX7, linked to higher EV production, and EVs contain miRNAs (miR-25, miR-92a, miR-30c, miR-30d) that enhance tumor invasiveness and metastasis.
In older patients, reduced expression of miRNA target genes PTEN and LATS2 and increased epithelial-mesenchymal transition are observed in metastatic tumors.
Therapeutically, targeting senescence with dasatinib and quercetin, inhibiting P2RX7, or silencing EV-associated miRNAs reduces metastasis in aged mice.

Hasty Briefsbeta