Individual participant-level analysis of four randomized clinical trials examined therapeutic effects of blood pressure lowering on hierarchical kidney outcome using win statistics - PubMed
3 hours ago
- #win statistics
- #blood pressure lowering
- #kidney outcomes
- Intensive blood pressure lowering showed unfavorable effects on kidney outcomes using hierarchical composite endpoints in SPRINT (Win Odds 0.61) and ACCORD-BP (Win Odds 0.64).
- In SHEP, chlorthalidone was inferior to placebo (Win Odds 0.89); in ALLHAT, doxazosin (Win Odds 1.29) and amlodipine (Win Odds 1.38) outperformed chlorthalidone, while lisinopril was slightly less favorable (Win Odds 0.96).
- The eGFR slope contributed over 50% to win statistics across trials, highlighting its role as a sensitive indicator of kidney reserve depletion.
- Findings suggest monitoring kidney function is important to balance cardiovascular protection and kidney preservation during intensive BP treatment.