Recurrent Second-Trimester Euploid Pregnancy Loss Associated With Maternal-Paternal HLA Compatibility: Review Based on a Case Report of Immune-Mediated Failure - PubMed
6 days ago
- #HLA
- #alloimmune
- #recurrent pregnancy loss
- Recurrent pregnancy loss (RPL) is often unexplained, with emerging evidence suggesting an alloimmune contribution in some cases.
- Excessive maternal-paternal HLA compatibility is proposed as a mechanism impairing maternal-fetal immune tolerance.
- A clinical case involved recurrent second-trimester euploid losses despite multimodal immunotherapy, including IVIG, corticosteroids, and other treatments.
- HLA typing showed allele sharing across four of five loci, indicating reduced immunogenetic diversity at the maternal-fetal interface.
- This case aligns with theories of impaired trophoblast-immune signaling and inadequate tolerance induction due to HLA sharing.
- The review highlights the need for individualized immunologic assessment and further research into targeted therapies for alloimmune-mediated reproductive failure.