Rejuvenation of THY1+ nucleus pulposus-derived stem cells promotes intervertebral disc regeneration through FGF10-FGFR1-CREB pathway and mitochondrial fission - PubMed
12 hours ago
- #Stem cell regeneration
- #FGF10
- #Intervertebral disc degeneration
- THY1+ nucleus pulposus-derived stem cells (NPSCs) are key in intervertebral disc degeneration (IVDD) and regeneration.
- FGF10 is identified as a pivotal rejuvenation factor for THY1+ NPSCs, mitigating senescence via the FGF10-FGFR1-CREB pathway.
- The FGF10-FGFR1 axis alleviates mitochondrial fission by inhibiting CREB phosphorylation and downregulating ARG2-DRP1-related pathways.
- Transplantation of FGF10-overexpressing NPSCs shows potential in alleviating disc degeneration and promoting regeneration in vivo.
- The study highlights the therapeutic potential of targeting THY1+ NPSCs and FGF10 for IVDD treatment.