Exploring the molecular mechanisms underlying the inflammation-cancer transformation in Hashimoto thyroiditis using single-cell transcriptomics - PubMed
12 hours ago
- #Single-cell transcriptomics
- #Papillary thyroid carcinoma
- #Hashimoto thyroiditis
- Hashimoto thyroiditis (HT) is linked to papillary thyroid carcinoma (PTC), but the mechanisms are unclear.
- Single-cell RNA sequencing identified 11 cell subtypes in HT and PTC tissues, including malignant epithelial cells.
- IL1B was upregulated in malignant follicular epithelial cells (FECs), enriching immune-related processes.
- IL1B-FECs communicate with mast cells via the FN1/CD44 signaling axis.
- Mast cells secrete IL-8 under inflammation, activating PI3K/AKT pathway to promote malignancy.
- The study provides insights into the inflammation-to-cancer transition in HT-PTC.