Dynamic MRI of Fluid and Solute Transportation across the Arachnoid Barrier in the Human Meninges - PubMed
3 hours ago
- #Arachnoid Barrier
- #MRI
- #Meninges
- Dynamic MRI study on fluid and solute transport across the arachnoid barrier in human meninges.
- Aims to establish a clinically feasible intravenous gadolinium-based contrast agent (GBCA)-based MRI approach.
- Study conducted from September 2023 to September 2024 with 20 healthy participants.
- High-resolution structural MRI and dynamic dual spin-echo perfusion (DDSEP) MRI used to track GBCA distribution.
- GBCA enhancement detected in meningeal subregions, with blood and CSF signal changes observed at different time intervals.
- Delayed GBCA-induced CSF signal intensity changes in SAS around bridging veins compared to the superior sagittal sinus.
- Demonstrates the feasibility of DDSEP MRI in measuring dynamic fluid and solute transport across the arachnoid barrier.