Methyl jasmonate promotes host defense by activating autophagy during Mycobacterium tuberculosis infection - PubMed
4 hours ago
- #Mycobacterium tuberculosis
- #Autophagy
- #Host defense
- Methyl jasmonate (MeJA) enhances host defense against Mycobacterium tuberculosis (Mtb) by activating autophagy.
- MeJA does not directly kill Mtb but boosts antimicrobial responses in macrophages and in vivo, including against multidrug-resistant strains.
- MeJA reduces proinflammatory cytokines and chemokines in macrophages and lung tissues during infection.
- MeJA inhibits the AKT-MTOR axis, promoting autophagy and lysosomal gene expression via transcription factor EB nuclear translocation.
- MeJA activates autophagy, improving phagosomal maturation and antimicrobial responses.
- The study suggests MeJA as a potential plant-derived host-directed therapy for tuberculosis.