Cross-tissue integrative transcriptomic and multimodal analyses suggest shared immune signatures linking lupus nephritis and cutaneous lupus erythematosus - PubMed
a day ago
- #cutaneous lupus erythematosus
- #lupus nephritis
- #transcriptomics
- Shared immune signatures between lupus nephritis (LN) and cutaneous lupus erythematosus (CLE) were identified using integrative transcriptomic and multimodal analyses.
- 361 DEGs in LN and 711 DEGs in CLE were found, with 99 overlapping genes, highlighting immune-related pathways like type I interferon signaling.
- Machine learning identified six hub genes (PDE4B, ISG20, IFI27, PARP12, IFI44, GATA3) with diagnostic potential (AUC >0.7).
- Single-cell RNA sequencing confirmed hub gene expression in T cells, B cells, and NK cells, linking them to immune dysregulation.
- Validation in Lpr mice showed elevated IFN-β levels and altered CD4/CD8 ratios, aligning with human findings.
- The study suggests these hub genes as potential therapeutic targets for improving lupus comorbidity management.