N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93 - PubMed
2 hours ago
- #METTL3-NUP93 axis
- #N6-adenosine methylation
- #mRNA export
- N6-adenosine methylation (m6A) accelerates nuclear mRNA export by increasing efficiency and reducing export time.
- METTL3, an m6A methyltransferase, localizes at nuclear pore complexes (NPCs) and associates with nucleoporin NUP93 to facilitate m6A-modified mRNA export.
- Disruption of the METTL3-NUP93 interaction impairs mRNA export efficiency.
- A steroid-resistant nephrotic syndrome (SRNS)-linked NUP93 variant (Arg388Trp) fails to bind METTL3, leading to defective export of kidney function-related mRNAs.
- The study identifies the m6A-METTL3-NUP93 axis as a critical regulator of nuclear mRNA export with implications for human diseases.