Home-based sleep monitoring reveals associations between amyloid accumulation and sleep alterations in individuals with subjective and mild cognitive impairment - PubMed
4 hours ago
- #Cognitive Impairment
- #Alzheimer's Disease
- #Sleep Monitoring
- Sleep disturbances were studied in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) using portable home-based monitoring.
- MCI patients showed reduced deep sleep (N3), while SCD individuals had longer light sleep (N1) duration compared to cognitively unimpaired participants.
- Regional amyloid burden was associated with longer light and deep sleep durations in amyloid-positive individuals, linking sleep alterations to brain pathology.
- Higher education levels were correlated with better sleep efficiency, suggesting a protective factor.
- Sleep changes may serve as early indicators of cognitive dysfunction and amyloid accumulation in preclinical Alzheimer's disease stages.