Effects of Exercise on Cognitive Impairment in Patients Receiving Chemotherapy: A Multicenter Phase III Randomized Controlled Trial - PubMed
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- Up to 75% of patients experience cancer-related cognitive impairment (CRCI) during treatment.
- Exercise may reduce CRCI and mental fatigue by promoting immunocompetence and regulating inflammatory responses.
- A 6-week home-based exercise intervention (EXCAP) was tested against usual care in a multicenter phase III randomized controlled trial.
- EXCAP participants on 2-week chemotherapy cycles reported less cognitive impairment and mental fatigue compared to usual care.
- Suppressed inflammatory responses were linked to CRCI, suggesting a role for inflammation in cognitive impairment during chemotherapy.
- The study concludes that EXCAP can reduce CRCI and mental fatigue, especially in patients on 2-week chemotherapy cycles.