Targeting phenol-soluble modulin α3-driven M1 macrophage polarization and necroptosis mitigates MRSA infection in mice - PubMed
7 hours ago
- #necroptosis
- #MRSA infection
- #macrophage polarization
- Phenol-soluble modulin α3 (PSMα3) drives M1 macrophage polarization and necroptosis via ISGF3-necrosome interaction and FPR2 receptor in MRSA infections.
- Targeting STAT1 with fludarabine mitigates MRSA infection in mouse models, suggesting anti-virulence strategies as potential therapies.
- The study addresses MRSA's antibiotic resistance by uncovering virulence mechanisms, highlighting the need for novel treatment approaches.