Insulin-like growth factor signaling regulates zebrafish lymphatic-vessel development - PubMed
6 days ago
- #lymphangiogenesis
- #zebrafish development
- #IGF signaling
- The insulin-like growth factor (IGF) signaling pathway plays a crucial role in zebrafish lymphatic vessel development.
- The medial facial lymphatic (MFL) vessel development depends on hyoid arch cartilage, with pregnancy-associated plasma protein A2 (pappa2) potentially mediating this interaction.
- Pappa2 cleaves IGF-binding proteins (IGFBPs), specifically Igfbp3 and Igfbp5b, which are expressed near the hyoid cartilage.
- Manipulations such as IGF overexpression or IGFBP inhibition enhance MFL growth, while pappa2 knockdown or IGF1R inhibition suppress it.
- IGF signaling has a cell-autonomous role in lymphatic development, with human LECs derived from iPSCs responding to IGF2 by migrating.
- The study underscores the significance of IGF signaling in lymphangiogenesis, linking cartilage interactions to lymphatic network formation.