Nanomotor-Driven Extracellular Vesicles With Effective Tissue Penetration for Targeted Therapy of Primary Ovarian Insufficiency - PubMed
3 hours ago
- #hydrogel
- #nanomotor
- #extracellular vesicles
- Stem cells and extracellular vesicles (EVs) offer potential for treating premature ovarian insufficiency (POI).
- Clinical use of EVs is limited by instability, poor tissue penetration, and lack of targeted delivery.
- A new injectable hydrogel with nanomotor-driven EVs (LEVs-Gel) is introduced for targeted POI therapy.
- LEVs-Gel leverages ROS and iNOS in the POI ovarian microenvironment to enhance chemotaxis and penetration.
- The hydrogel improves EV retention and stability, restoring ovarian function and fertility in POI mice.
- Therapeutic effects include oxidative balance maintenance, apoptosis inhibition, and promotion of angiogenesis.