Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease - PubMed
3 hours ago
- #LDL cholesterol
- #clinical trial
- #cardiovascular disease
- Intensive LDL cholesterol targeting (<55 mg/dL) in patients with atherosclerotic cardiovascular disease reduces cardiovascular events compared to conventional targeting (<70 mg/dL).
- The trial showed a hazard ratio of 0.67 (95% CI: 0.52 to 0.86) for the primary composite endpoint over 3 years, favoring intensive targeting.
- Safety endpoints were similar between groups, except for lower creatinine elevation in the intensive-targeting group.
- The median LDL cholesterol achieved was 56 mg/dL in the intensive group and 66 mg/dL in the conventional group.
- Results support intensive LDL lowering for secondary prevention in atherosclerotic cardiovascular disease.