The use of GLP-1 receptor agonists and co-agonists in adults without diabetes: a systematic review and network meta-analysis protocol - PubMed
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- #Network meta-analysis
- #GLP-1 receptor agonists
- #Obesity
- Systematic review and network meta-analysis (NMA) protocol to assess GLP-1 receptor agonists (RAs) and co-agonists for weight loss in adults without diabetes.
- Primary outcome: weight loss (relative change from baseline) at 6 months (±4 weeks) and 1-1.5 years (±4 weeks).
- Secondary outcomes include absolute body weight change, adverse events (total, gastrointestinal, serious), and death.
- Databases searched: PubMed, Ovid, Cochrane CENTRAL for randomized controlled trials (RCTs).
- Exclusion criteria: participants with diabetes, specific comorbidities, or history of bariatric surgery.
- Analysis methods: pairwise meta-analyses, frequentist NMAs using random-effects model, treatment rankings via surface under the cumulative ranking curve.
- Quality assessment tools: Cochrane Risk of Bias (RoB) 2 for study-level, RoB-NMA for network quality.
- Aim: Provide evidence for clinical decision-making, guideline development, and policy decisions regarding GLP-1 RAs and co-agonists in non-diabetic adults.
- Conflict of interest: Some authors received speaker honoraria from pharmaceutical companies unrelated to this work.