Glucagon-Like Peptide-1 Receptor Agonism and Muscle Health: Vascular and Myocellular Effects on Glucose and Protein Metabolism - PubMed
3 hours ago
- #protein turnover
- #muscle metabolism
- #GLP-1 RA
- GLP-1 receptor agonists (GLP-1 RAs) improve glycaemia and reduce body weight, but their effects on skeletal muscle are not fully understood.
- GLP-1 RAs recruit microvasculature in muscle, enhancing capillary surface area and improving delivery of insulin, glucose, and amino acids.
- Microvascular recruitment increases interstitial insulin availability, boosting insulin-stimulated glucose uptake and glycogen synthesis.
- Direct effects of GLP-1 on muscle cells are still under investigation.
- For protein metabolism, GLP-1 RAs may enhance muscle protein synthesis when amino acid availability is high, but effects under fasting conditions are unclear.
- The presence of GLP-1 receptors in human muscle cells is uncertain, which complicates understanding direct versus perfusion-mediated actions.
- Clinically, GLP-1 RAs reduce lean body mass, likely due to energy deficits, but studies on muscle mass are limited.
- GLP-1 RAs show beneficial effects on muscle vasculature and glucose metabolism, but their impact on protein turnover remains unclear.
- Preclinical data suggest potential favorable effects on muscle protein metabolism, but human studies are needed for confirmation.