Self-regulating hydrogel for diabetic wound healing: From animal models to a pilot clinical study - PubMed
10 hours ago
- #clinical study
- #self-regulating hydrogel
- #diabetic wound healing
- Chronic diabetic wounds are a major health issue, often leading to amputations due to factors like infection, inflammation, and poor angiogenesis.
- Researchers developed a self-regulating hydrogel called GPP@ZnBG that responds to elevated glucose and oxidative stress in diabetic wounds.
- The hydrogel releases therapeutic ions in a pH-regulated, sequential manner: zinc ions early for antibacterial effects, and zinc, calcium, and silicate ions later to support angiogenesis, reduce inflammation, and promote tissue repair.
- In diabetic mice, the hydrogel improved wound closure by enhancing neovascularization and collagen deposition, and single-cell RNA sequencing showed it modulates fibroblast behavior to reduce inflammation.
- A pilot clinical study reported a 94.57% relative reduction in wound surface area within four weeks with no adverse events, indicating promising therapeutic potential.