Genetic landscaping of cell competition uncovers two core pathways mediated by Xrp1 or Eiger/TNF in Drosophila - PubMed
12 hours ago
- #Xrp1-Eiger Pathways
- #Cell Competition
- #Drosophila Genetics
- Genetic studies in Drosophila identified diverse molecules driving cell competition, a quality-control mechanism eliminating less-fit cells.
- A large-scale genetic screen across ~12,500 mutant chromosomes isolated 63 mutations converting cells into 'losers' of cell competition.
- Two core pathways mediate cell competition: the bZip transcription factor Xrp1 and the Eiger/TNF-JNK signaling pathway.
- Genomic analyses revealed genes for nucleocytoplasmic mRNA export (Xrp1 pathway) and septate junction function (Eiger/TNF pathway) are key.
- Cell competition acts as a surveillance system detecting cellular malfunctions and eliminating defective cells via Xrp1 or Eiger/TNF pathways.