A spontaneous termination mechanism of RNA polymerase V shapes the DNA methylation landscape in plants - PubMed
5 hours ago
- #Transcription Termination
- #RNA Polymerase V
- #DNA Methylation
- RNA Polymerase V (Pol V) terminates at A-rich DNA templates (A-rich-DNAT), which defines DNA methylation boundaries in plants.
- Structural studies show that unstable rU:dA pairs in the RNA-DNA hybrid cause transcription bubble collapse and spontaneous termination.
- This intrinsic termination mechanism shapes genomic DNA methylation patterns, crucial for gene silencing and transposon suppression.