Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial-the Hiroshima
6 days ago
- #colorectal-cancer
- #chemotherapy
- #peripheral-neuropathy
- Study evaluates surgical glove compression therapy to prevent oxaliplatin-induced peripheral neuropathy (OIPN) in colorectal cancer patients.
- Multicentre, randomised, open-label, phase II/III trial with 170 patients planned for enrollment.
- Intervention group wears two layers of tight-fitting surgical gloves during oxaliplatin infusion.
- Primary endpoint is incidence of grade ≥2 chemotherapy-induced peripheral neuropathy (CIPN).
- Secondary endpoints include quality of life assessments, duration/extent of OIPN, and chemotherapy completion rates.
- Approved by Hiroshima University's Institutional Review Board and registered with Japan Registry of Clinical Trials.
- Results to be published in peer-reviewed journals and presented at international conferences.